Nonsense Surveillance in Lymphocytes?
نویسندگان
چکیده
منابع مشابه
The nonsense-mediated decay RNA surveillance pathway.
Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination (nonsense) codons. If translated, these mRNAs can produce truncated proteins with dominant-negative or deleterious gain-of-function activities. In this review, we describe the molecular mechanism of NMD. We first cover conserved factors known to be involved in NMD in...
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the disposal of nonfunctional by-products of normal The robustness of biological systems depends on the RNA processing. function of proofreading mechanisms against operating NMD—An Enigma in RNA Metabolism errors. Studies in yeast and of human genetic disorders NMD has captured much attention as one of the most have lead the way to a conserved surveillance mechaenigmatic processes in RNA metabo...
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Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved mRNA surveillance system that degrades mRNA transcripts that harbour a premature translation-termination codon (PTC), thus reducing the synthesis of truncated proteins that would otherwise have deleterious effects. Although extensive research has identified a conserved repertoire of NMD factors, these studies have been performed ...
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ژورنال
عنوان ژورنال: Immunity
سال: 1998
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80466-5